For ordinary itchy bites, the safest first moves are simple: wash the area, use a cold compress, avoid scratching, and choose gentle topical support. Aloe, calendula, colloidal oatmeal, and clean plantain poultices are common low-risk options when used on intact skin.
When not to DIY
Trouble breathing, facial swelling, dizziness, widespread hives, fever, pus, severe pain, or spreading redness deserves medical care. Tick bites and suspected venomous bites need extra caution.
Start here: Bug Bites, Mosquito Bites, and Aloe Vera.